Water, energy, and food are the most critically important resources for society, particularly in meeting Sustainable Development Goals (SDGs). The demand for these resources will increase in future decades because of climate change, population growth, and socioeconomic forces. This growing demand is creating more trade-offs and conflicts, particularly among groundwater resources and stakeholders in both developed and developing countries. These conflicts have exacerbated the challenges of managing sustainable groundwater and coupled food and energy resources. This complex relationship between water, energy, and food resources and climate change is called the water-energy-food (WEF) Nexus. There is a research need to quantify the impacts and feedbacks of the WEF Nexus and identify how those concepts may help scientists and resource managers design optimal groundwater sustainability (WEF-GW Nexus) plans to best meet diverse stakeholder interests. Our WEF-GW Nexus project uses a transdisciplinary approach that integrates different knowledge systems from developed and developing countries; including those from academic researchers, early-career scientist and students, farmers, and other groundwater users and practitioners from rural and urban communities, local resource agencies, and other stakeholders. We will also hold training and knowledge transfer workshops, creating a dialogue about science and research to advance management, policy, and stakeholder engagement that leads to sustainable groundwater within the WEF-GW Nexus. To address the identified lack of WEF-GW studies, the WEF-GW Nexus project has established a global collaboration in 2019 of dozens of participants from three continents, and is supported by the International Geoscience Programme and UNESCO-GRAPHIC. The WEF-GW Nexus collaboration targets groundwater basins on three continents —Africa, America, and Europe — containing vast groundwater resources with an estimated dependence of tens of millions of people. We will present the WEF-GW Nexus project, show examples from groundwater basins, and discuss collaboration possibilities to integrate groundwater information from these regions.