In undifferentiated geologic terrains as Kintampo South District in Brong-Ahafo Region of Ghana, there is the need for extensive groundwater exploration before suitable sites are selected for drilling. There is therefore the need to augment the groundwater investigation to improve the success of drilled holes and to reduce the cost of drilling unsuccessful wells. The use of the polluted surface waters which are the primary water supplies within the District has resulted in outbreak of several water borne diseases. An alternative water supply system which is reliable and cost effective is imperative to complement the traditional surface water supply system. This study seeks to integrate Electromagnetic (EM) and Vertical Electrical Sounding (VES) methods to locate suitable aquifers for groundwater extraction within the Kintampo South District. Hydro geological investigations were carried out within ten selected communities within the District using the EM and VES geophysical methods. The EM was used for horizontal profiling and selected anomalous points/areas further investigated with the VES, after which points were ranked and finally selected for drilling. The electromagnetic profiling was efficient in detecting anomalies and possible water filled fractures as was further confirmed by the VES survey. Ninety percent (90%) of the drill points selected for drilling produced wet wells which increased access to water, sanitation and hygiene (WASH), and a reduction in water borne diseases and other WASH related issues within the district. It is recommended that more than one geophysical method should be combined for better and effective results. This method can be used to map out potential drilling points for groundwater supplies/help to improve on sites selection and reduce the drilling of unsuccessful wells. This will enable the limited financial resources in developing countries to be channelled into providing boreholes with substantial yields.